USHealthcare

Spyre Therapeutics Inc. (SYRE)

US · Healthcare · Biotechnology

$104.94+10.54%
Last close · 2026-08-04

Latest quarter · ended 2026-03-31

Revenue
$0
Net profit
$-69.0M
Profit YoY
-54.1%
EPS
$-0.74
EPS estimate
$-0.64

EPS came in at -0.74 against a street estimate of -0.64 — a miss of 14.8%.

Key statistics

Market cap
$8.54B
Forward P/E
0.0
P/B
16.58
Book value
$6.53
EPS (TTM)
$-2.12
52-week high
$105.09
52-week low
$14.51
50-day MA
$87.66
200-day MA
$52.38
Beta
3.02

Analyst view

Analysts rate Spyre Therapeutics Inc. a strong buy (10 buy, 1 hold, 0 sell out of 11) with an average price target of $105.79.

Shareholding

Insiders
5.86%
Institutions
93.56%

Largest institutional holders

FundStake
FMR Inc13.57%
BlackRock Inc6.36%
RTW INVESTMENTS, LLC4.80%
Fairmount Funds Management LLC4.63%
Perceptive Advisors LLC4.36%
VR Adviser, LLC4.24%
Vanguard Capital Management, LLC3.52%
Driehaus Capital Management LLC3.21%

Recent filings & reports

DocumentDate
Reg FD disclosure · Q2 20262026-06-15
Company announcement · Q2 20262026-06-01
Board / officer change · Q2 20262026-05-29
Results announced · Q2 20262026-05-05
Quarterly report · Q1 20262026-05-05
Proxy statement · Q2 20262026-04-10
Annual report FY20252026-02-19
Quarterly report · Q3 20252025-11-04

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Data updated 2026-08-05.